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Int J Clin Exp Pathol. 2013 Nov 15;6(12):2668-74. eCollection 2013.

Regulatory T cells and B cells: implication on autoimmune diseases.

Author information

1
Division of Liver Transplantation Surgery, The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road, Nanjing, 210029, China.

Abstract

The regulatory T (Treg) cells play an important role in the maintenance of homeostasis and the prevention of autoimmune diseases. Although most studies are focusing on the role of Treg cells in T cells and T cells-mediated diseases, these cells also directly affect B cells and other non-T cells. This manuscript updates the role of Treg cells on the B cells and B cell-mediated diseases. In addition, the mechanisms whereby Treg cells suppress B cell responses have been discussed.

KEYWORDS:

B cells; Foxp3; Treg; antibodies; autoimmune diseases

PMID:
24294353
PMCID:
PMC3843247
[Indexed for MEDLINE]
Free PMC Article

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