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Nucleic Acids Res. 2014 Jan;42(Database issue):D310-4. doi: 10.1093/nar/gkt1242. Epub 2013 Nov 29.

SCOP2 prototype: a new approach to protein structure mining.

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MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK and European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK.

Erratum in

  • Nucleic Acids Res. 2014 Oct;42(18):11847.


We present a prototype of a new structural classification of proteins, SCOP2 (, that we have developed recently. SCOP2 is a successor to the Structural Classification of Proteins (SCOP, database. Similarly to SCOP, the main focus of SCOP2 is to organize structurally characterized proteins according to their structural and evolutionary relationships. SCOP2 was designed to provide a more advanced framework for protein structure annotation and classification. It defines a new approach to the classification of proteins that is essentially different from SCOP, but retains its best features. The SCOP2 classification is described in terms of a directed acyclic graph in which nodes form a complex network of many-to-many relationships and are represented by a region of protein structure and sequence. The new classification project is expected to ensure new advances in the field and open new areas of research.

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