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Nucleic Acids Res. 2014 Jan;42(Database issue):D310-4. doi: 10.1093/nar/gkt1242. Epub 2013 Nov 29.

SCOP2 prototype: a new approach to protein structure mining.

Author information

  • 1MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK and European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK.

Erratum in

  • Nucleic Acids Res. 2014 Oct;42(18):11847.

Abstract

We present a prototype of a new structural classification of proteins, SCOP2 (http://scop2.mrc-lmb.cam.ac.uk/), that we have developed recently. SCOP2 is a successor to the Structural Classification of Proteins (SCOP, http://scop.mrc-lmb.cam.ac.uk/scop/) database. Similarly to SCOP, the main focus of SCOP2 is to organize structurally characterized proteins according to their structural and evolutionary relationships. SCOP2 was designed to provide a more advanced framework for protein structure annotation and classification. It defines a new approach to the classification of proteins that is essentially different from SCOP, but retains its best features. The SCOP2 classification is described in terms of a directed acyclic graph in which nodes form a complex network of many-to-many relationships and are represented by a region of protein structure and sequence. The new classification project is expected to ensure new advances in the field and open new areas of research.

PMID:
24293656
PMCID:
PMC3964979
DOI:
10.1093/nar/gkt1242
[PubMed - indexed for MEDLINE]
Free PMC Article
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