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Pediatr Blood Cancer. 2014 May;61(5):768-70. doi: 10.1002/pbc.24886. Epub 2013 Nov 30.

Fetal alcohol spectrum disorders and childhood cancer: a concise review of case reports and future research considerations.

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Department of Pediatrics, North Dakota Fetal Alcohol Syndrome Center, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota.


We reviewed the published literature on the relationship between childhood cancer and fetal alcohol spectrum disorders (FASD). A Pub Med search identified 12 subjects with the co-occurrence of FASD and cancer. We included an additional case from the author's institution. Neuroblastomas comprised 6 of the 13 (46%) case reports, yet neuroblastomas comprise only about 10% of childhood cancers (z = 4.1; P < 0.001). Other than rhabdomyosarcoma, no other cancer was reported more than once. Few cases of childhood cancer associated with FASD were identified likely due to under ascertainment of FASD.


alcohol; cancer; children; fetal alcohol spectrum disorders; pregnancy; prevalence

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