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Handb Exp Pharmacol. 2014;219:281-92. doi: 10.1007/978-3-642-41199-1_14.

Arrestin-mediated activation of p38 MAPK: molecular mechanisms and behavioral consequences.

Author information

1
Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA, cchavkin@u.washington.edu.

Abstract

Studies of kappa opioid receptor signaling mechanisms during the last decade have demonstrated that agonist activation of the receptor results in Gβγ-dependent signaling and distinct arrestin-dependent signaling events. Gβγ-dependent signaling results in ion channel regulation causing neuronal inhibition, inhibition of transmitter release, and subsequent analgesic responses. In contrast, arrestin-dependent signaling events result in p38 MAPK activation and subsequent dysphoric and proaddictive behavioral responses. Resolution of these two branches of signaling cascades has enabled strategies designed to identify pathway-selective drugs that may have unique therapeutic utilities.

PMID:
24292835
DOI:
10.1007/978-3-642-41199-1_14
[Indexed for MEDLINE]

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