Format

Send to

Choose Destination
See comment in PubMed Commons below
Inflammation. 2014 Apr;37(2):581-92. doi: 10.1007/s10753-013-9772-2.

Diverse roles of natural killer T lymphocytes in liver and spleen in mice with experimental autoimmune uveitis.

Author information

1
Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, No. 48#, Yingxiongshan Road, Jinan, 250002, China.

Abstract

Natural killer T lymphocytes (NKT cells) have diverse roles in different organs. However, it is still unclear whether NKT cells play different roles in the liver and spleen in mice with experimental autoimmune uveitis. In the present study, we explored their diverse roles of NKT cells in the liver and spleen and found that liver-derived NKT cells could efficiently inhibit Th1 and Th17 differentiation, whereas the function of spleen-derived NKT cells was less potent. Meanwhile, the occurrence of the peak ratios of NKT cells/T cells in the spleen and liver was markedly asynchronous after immunization. Moreover, different methods of immunization could result in different immune responses in mice. Furthermore, the memory response was also found in the generation of NKT cells in mice when they received the same antigen. These results indicate that the functional roles of NKT cells possess diversity in the spleen and liver in mice with experimental autoimmune uveitis.

PMID:
24292798
DOI:
10.1007/s10753-013-9772-2
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center