Shown in the middle is a table listing the major families of 5-HT receptors (viz. 5-HT1 to 5-HT7). As shown, the 5-HT1 family has five members (5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F), while the 5-HT2 family — the topic of this review — has three: 5-HT2A, 5-HT2B, and 5-HT2C. Each member of the 5-HT2 family displays distinct brain and tissue distributions. The 5-HT2A receptor is enriched in pyramidal neurons in layer V of the cerebral cortex, where it mediates the actions of pimavanserin and other atypical antipsychotic drugs. The 5-HT2B receptor is enriched in interstitial cells of the heart valves, where it mediates the valvulopathic actions of certain drugs like fenfluramine. The 5-HT2C receptor is enriched in the hypothalamus, among other areas, particularly in nuclei engaged in regulating feeding behavior, where it mediates the actions of the appetite suppressant lorcaserin.