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Nature. 1986 Oct 9-15;323(6088):558-60.

The hepatitis delta (delta) virus possesses a circular RNA.

Abstract

Hepatitis delta (delta) virus (HDV), a satellite virus of the hepatitis B virus (HBV), causes a severe form of viral hepatitis in humans. Here we present evidence based on electron microscopy and electrophoretic behaviour that HDV contains a single stranded circular RNA molecule. This is the first animal virus identified with a circular RNA genome. Circular RNAs have only been found in plant viruses. We have obtained a partial complementary DNA clone representing approximately 25% of the total genome of HDV. Analysis of this cDNA revealed similarity to two plant viruses that may explain the origin of the virus.

PMID:
2429192
DOI:
10.1038/323558a0
[Indexed for MEDLINE]

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