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Breast. 2014 Feb;23(1):94-6. doi: 10.1016/j.breast.2013.11.002. Epub 2013 Dec 2.

MarginProbe®--final results of the German post-market study in breast conserving surgery of ductal carcinoma in situ.

Author information

1
Department of Gynecology and Obstetrics, Agaplesion Markus Hospital, Germany. Electronic address: marc.thill@fdk.info.
2
Breast Cancer Center, Hospital Essen Mitte, Germany.
3
Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Germany.
4
Mammazentrum Hamburg, Germany.
5
Department of Gynecology and Obstetrics, St. Gertrauden Hospital, Berlin, Germany.

Abstract

The goal in breast conserving surgery (BCS) of ductal carcinoma in situ (DCIS) is removal of the tumor with a clear surgical margin. However, re-excision rates are regrettably high. To date, there are no adequate procedures for intraoperative margin assessment of DCIS. A multicenter, single arm study was conducted to evaluate the benefit of a novel device (MarginProbe®) in intraoperative margin assessment during BCS of DCIS, the associated reduction of re-excisions and the cosmetic outcome of the treated patients. We present results of 42 patients enrolled in 3 German institutions. The device was used as an adjunctive tool to standard of care. The device use was associated with a reduction in re-excision rates by 56%, from 39% to 17% (p = 0.018).

KEYWORDS:

Breast conservation surgery; Ductal carcinoma in situ; Intraoperative margin assessment; Radiofrequency spectroscopy; Surgical margins

PMID:
24291375
DOI:
10.1016/j.breast.2013.11.002
[Indexed for MEDLINE]

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