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Eur J Pharmacol. 2014 Sep 15;739:19-25. doi: 10.1016/j.ejphar.2013.10.072. Epub 2013 Nov 28.

Calcium channels, external calcium concentration and cell proliferation.

Author information

1
INSERM U1003, LabEx ICST, Université Lille 1, Villeneuve d'Ascq F-59655, France.
2
INSERM U845, Research Center Growth and Signalling Research Center, Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Bâtiment Leriche, 96 rue Didot, Paris F-75993, France.
3
INSERM U845, Research Center Growth and Signalling Research Center, Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Bâtiment Leriche, 96 rue Didot, Paris F-75993, France. Electronic address: thierry.capiod@inserm.fr.

Abstract

Evidence for a role for calcium channel proteins in cell proliferation is numerous suggesting that calcium influx is essential in this physiological process. Several studies in the past thirty years have demonstrated that calcium channel expression levels are determinant in cell proliferation. Voltage-gated, store-operated, second messengers and receptor-operated calcium channels have been associated to cell proliferation. However, the relationship between calcium influx and cell proliferation can be uncoupled in transformed and cancer cells, resulting in an external calcium-independent proliferation. Thus, protein expression could be more important than channel function to trigger cell proliferation suggesting that additional channel functions may be responsible to reconcile calcium channel expression and cell proliferation. When needed, external calcium concentration is obviously important for calcium channel function but it also regulates calcium sensing receptor (CaSR) activity. CaSR can up- or down-regulate cell proliferation depending on physiological conditions. CaSR sensitivity to external calcium is within the 0.5 to 5 mM range and therefore, the role of these receptors in cell proliferation must be taken into account. We therefore suggest here that cell proliferation rates could depend on the relative balance between calcium influx and CaSR activation.

KEYWORDS:

Calcium channels; Calcium sensing receptor; Cell cycle; Cell proliferation

PMID:
24291106
DOI:
10.1016/j.ejphar.2013.10.072
[Indexed for MEDLINE]

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