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J Neuroimmunol. 2014 Jan 15;266(1-2):67-74. doi: 10.1016/j.jneuroim.2013.11.005. Epub 2013 Nov 16.

Oxidative modification of blood serum proteins in multiple sclerosis after interferon or mitoxantrone treatment.

Author information

1
Department of Biochemistry and Cell Biology, University of Rzeszow, ul. Zelwerowicza 4, 35-601 Rzeszów, Poland. Electronic address: isadowska@poczta.fm.
2
Department of Neurology in Zabrze, Medical University of Silesia, ul. 3-go Maja 13-15, 41-800 Zabrze, Poland.
3
Department of Molecular Biophysics, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland.
4
Department of Biochemistry and Cell Biology, University of Rzeszow, ul. Zelwerowicza 4, 35-601 Rzeszów, Poland; Department of Molecular Biophysics, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland.

Abstract

This study was aimed at (i) comparison of the usefulness of serum protein oxidation parameters for assessment of oxidative stress (OS) in multiple sclerosis (MS), and (ii) comparison of OS in MS patients subject to various therapies. Elevated glycophore level was noted in relapsing-remitting (RRMS) patients without treatment and patients treated with interferons β1a and β1b (10.33±3.27, 8.02±2.22 and 8.56±2.45 vs control 5.27±0.73 fluorescence units (FU)/mg protein). Advanced oxidation protein products (295±135 vs 83±65nmol/mg protein), carbonyl groups (3.68±1.44nmol/mg protein vs 2.03±0.23nmol/mg protein), kynurenine (7.71±0.1.67 vs 5.5±0.63 FU/mg protein) and N'-formylkynurenine (7.69±0.7 vs 4.97±0.59 FU/mg protein) levels were increased, while thioredoxin level was decreased in RRMS patients without treatment (5.03±2.18 vs 10.83±2.75ng/ml) with respect to control. The level of OS was higher in untreated RRMS patients and in SPMS patients treated with mitoxantrone than in patients treated with interferon.

KEYWORDS:

AGEs; Carbonyl groups; Mitoxantrone; Multiple sclerosis; Oxidative protein modifications; Thioredoxin

PMID:
24290230
DOI:
10.1016/j.jneuroim.2013.11.005
[Indexed for MEDLINE]

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