Format

Send to

Choose Destination
Science. 2013 Nov 29;342(6162):1237435. doi: 10.1126/science.1237435.

The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria.

Author information

1
Department of Physics, University of California at San Diego, La Jolla, CA 92093-0374, USA.

Abstract

To predict the emergence of antibiotic resistance, quantitative relations must be established between the fitness of drug-resistant organisms and the molecular mechanisms conferring resistance. These relations are often unknown and may depend on the state of bacterial growth. To bridge this gap, we have investigated Escherichia coli strains expressing resistance to translation-inhibiting antibiotics. We show that resistance expression and drug inhibition are linked in a positive feedback loop arising from an innate, global effect of drug-inhibited growth on gene expression. A quantitative model of bacterial growth based on this innate feedback accurately predicts the rich phenomena observed: a plateau-shaped fitness landscape, with an abrupt drop in the growth rates of cultures at a threshold drug concentration, and the coexistence of growing and nongrowing populations, that is, growth bistability, below the threshold.

PMID:
24288338
PMCID:
PMC4059556
DOI:
10.1126/science.1237435
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center