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Ann Hematol. 2014 Mar;93(3):361-74. doi: 10.1007/s00277-013-1967-y. Epub 2013 Nov 28.

The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia.

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Laboratory for Immunological and Molecular Cancer Research, Third Medical Department with Hematology, Oncology, Hemostaseology, Infectiology and Rheumatology, Paracelsus Medical University, Müllner Haupstraße 48, 5020, Salzburg, Austria.


The interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote CLL cell survival and proliferation. CD38 and CD49d are both independent prognostic risk parameters in CLL with important roles in shaping these interactions. Both are reported to influence CLL cell trafficking between blood and lymphoid organs as well as their survival and proliferation within the lymphoid organs, thereby impacting the pathophysiology of the disease. The expression of CD38 and CD49d is associated in the majority of cases, and they exist as part of macromolecular complexes. Here, we review the current evidence for the individual and associated contributions of these molecules to CLL pathophysiology.

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