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Mol Biol Cell. 2013 Dec;24(23):3585-7. doi: 10.1091/mbc.E13-03-0155.

Building synthetic cellular organization.

Author information

  • 1Department of Systems Biology, Harvard Medical School, Boston, MA 02115; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115.

Abstract

The elaborate spatial organization of cells enhances, restricts, and regulates protein-protein interactions. However, the biological significance of this organization has been difficult to study without ways of directly perturbing it. We highlight synthetic biology tools for engineering novel cellular organization, describing how they have been, and can be, used to advance cell biology.

PMID:
24288075
PMCID:
PMC3842987
DOI:
10.1091/mbc.E13-03-0155
[PubMed - indexed for MEDLINE]
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