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Oral Maxillofac Surg Clin North Am. 2014 Feb;26(1):91-9. doi: 10.1016/j.coms.2013.09.008.

Extraglandular manifestations of primary Sjögren's syndrome.

Author information

1
Division of Rheumatology, Allergy and Immunology, Department of Medicine, Winthrop University Hospital, Stony Brook School of Medicine, 120 Mineola Boulevard, Suite 410, Mineola NY 11501, USA; State University of New York at Stony Brook School of Medicine, Stony Brook, NY 11794, USA.

Abstract

Sjögren syndrome is a chronic autoimmune disease that typically affects the salivary and lacrimal glands. Aside from the common glandular signs and symptoms, Sjögren syndrome may also cause mononuclear infiltration and immune complex deposition involving extraglandular sites producing several extraglandular manifestations (EGM). The prevalence of EGMs varies greatly depending on the particular manifestation. This article examines the ways that EGMs may present in patients with primary Sjögren syndrome. The focus is on the more prevalent and significant EGMs including involvement of the nervous system, pulmonary manifestations, vasculitis associated with primary Sjögren syndrome, and arthropathy.

KEYWORDS:

Arthropathy; Extraglandular; Sjögren's syndrome; Vasculitis

PMID:
24287197
DOI:
10.1016/j.coms.2013.09.008
[Indexed for MEDLINE]

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