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J Infect Dis. 2014 May 15;209(10):1613-7. doi: 10.1093/infdis/jit667. Epub 2013 Nov 28.

HIV antibody characterization as a method to quantify reservoir size during curative interventions.

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1
Clinical Dental Research Core, National Institute of Dental and Craniofacial Research.

Abstract

Quantitative humoral profiling of recent samples from a human immunodeficiency virus (HIV)-infected adult who was cured following a delta32/delta32 CCR5 stem cell transplant in 2007 revealed no antibodies against p24, matrix, nucleocapsid, integrase, protease, and gp120, but low levels of antibodies against reverse transcriptase, tat, and gp41. Antibody levels to these HIV proteins persisted at high and stable levels in most noncontrollers, elite controllers, and antiretroviral-treated subjects, but a rare subset of controllers had low levels of antibodies against matrix, reverse transcriptase, integrase, and/or protease. Comprehensive HIV antibody profiles may prove useful for monitoring curative interventions.

KEYWORDS:

HIV-1; HIV-1 persistence; antibodies; elite controllers; serology; viral reservoirs

PMID:
24286982
PMCID:
PMC3997576
DOI:
10.1093/infdis/jit667
[Indexed for MEDLINE]
Free PMC Article
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