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FEBS J. 2014 Jan;281(1):63-73. doi: 10.1111/febs.12601. Epub 2013 Nov 28.

L1 retrotransposons, cancer stem cells and oncogenesis.

Author information

1
Cancer Biology Program, Mater Medical Research Institute, South Brisbane, Australia.

Abstract

Retrotransposons have played a central role in human genome evolution. The accumulation of heritable L1, Alu and SVA retrotransposon insertions continues to generate structural variation within and between populations, and can result in spontaneous genetic disease. Recent works have reported somatic L1 retrotransposition in tumours, which in some cases may contribute to oncogenesis. Intriguingly, L1 mobilization appears to occur almost exclusively in cancers of epithelial cell origin. In this review, we discuss how L1 retrotransposition could potentially trigger neoplastic transformation, based on the established correlation between L1 activity and cellular plasticity, and the proven capacity of L1-mediated insertional mutagenesis to decisively alter gene expression and functional output.

KEYWORDS:

Alu; EMT; L1; LINE-1; SVA; cancer genomics; oncogenesis; plasticity; retrotransposon; tumorigenesis

PMID:
24286172
PMCID:
PMC4160015
DOI:
10.1111/febs.12601
[Indexed for MEDLINE]
Free PMC Article

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