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J Labelled Comp Radiopharm. 2013 May 15;56(5):310-1. doi: 10.1002/jlcr.3050. Epub 2013 Apr 24.

Synthesis of [15, 16- ³H] beta-funaltrexamine.

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1
PerkinElmer Life Sciences & Technology Inc., 940 Winter Street, Waltham, MA, 02451, USA.

Abstract

Beta-funaltrexamine is a unique irreversible antagonist for the mu-opiate receptor and would be useful as a tritiated radioligand. Starting from high specific activity [15, 16-³H] naltrexone, [15, 16-³H] beta-funaltrexamine was synthesized and characterized by means of a two-step reductive amination-acylation process.

KEYWORDS:

beta-funaltrexamine; irreversible; opiate receptor; tritium

PMID:
24285378
DOI:
10.1002/jlcr.3050
[Indexed for MEDLINE]
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