Format

Send to

Choose Destination
See comment in PubMed Commons below
J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):114-9. doi: 10.1002/jlcr.3011.

(11) C and (18) F PET radioligands for the serotonin transporter (SERT).

Author information

1
Center for Systems Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.

Abstract

The serotonin transporter (SERT) has been implicated in a variety of neuropsychiatric disorders including depression, anxiety, and suicide, and is the target of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants. The availability of SERT-specific positron emission tomography (PET) radioligands will allow the SERT to be studied noninvasively in living subjects through PET imaging of the SERT and occupancy studies of SSRIs. Numerous diaryl sulfide and tropane derivatives have been developed and radiolabeled with (11) C or (18) F for imaging the SERT with PET.

KEYWORDS:

carbon-11; diaryl sulfide; fluorine-18; nortropane; positron emission tomography; serotonin transporter

PMID:
24285317
DOI:
10.1002/jlcr.3011
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center