Format

Send to

Choose Destination
Toxins (Basel). 2013 Nov 12;5(11):2138-60. doi: 10.3390/toxins5112138.

Clostridium perfringens epsilon toxin: a malevolent molecule for animals and man?

Author information

1
Biology Department, Wilson College, 1015 Philadelphia Avenue, Chambersburg, PA 17201, USA. brad.stiles@wilson.edu.

Abstract

Clostridium perfringens is a prolific, toxin-producing anaerobe causing multiple diseases in humans and animals. One of these toxins is epsilon, a 33 kDa protein produced by Clostridium perfringens (types B and D) that induces fatal enteric disease of goats, sheep and cattle. Epsilon toxin (Etx) belongs to the aerolysin-like toxin family. It contains three distinct domains, is proteolytically-activated and forms oligomeric pores on cell surfaces via a lipid raft-associated protein(s). Vaccination controls Etx-induced disease in the field. However, therapeutic measures are currently lacking. This review initially introduces C. perfringens toxins, subsequently focusing upon the Etx and its biochemistry, disease characteristics in various animals that include laboratory models (in vitro and in vivo), and finally control mechanisms (vaccines and therapeutics).

PMID:
24284826
PMCID:
PMC3847718
DOI:
10.3390/toxins5112138
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center