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J Am Heart Assoc. 2013 Nov 27;2(6):e000329. doi: 10.1161/JAHA.113.000329.

Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies.

Author information

1
Department of Epidemiology, School of Public Health, Soochow University, Suzhou, China.

Abstract

BACKGROUND:

Though vitamin C supplementation has shown no observed effects on stroke prevention in several clinical trials, uncertainty remains as to whether long-term, low-dose intake influences the development of stroke among general populations. Furthermore, the association between circulating vitamin C and the risk of stroke is also unclear. For further clarification of these issues, we conducted a meta-analysis of prospective studies.

METHODS AND RESULTS:

PubMed and EMBASE databases were searched, and the bibliographies of the retrieved articles were also reviewed to identify eligible studies. Summary relative risk (RRs) with corresponding 95% confidence intervals (CIs) were computed with a random-effects model. The summary RR for the high-versus-low categories was 0.81 (95% CI: 0.74 to 0.90) for dietary vitamin C intake (11 studies), and 0.62 (95% CI: 0.49 to 0.79) for circulating vitamin C (6 studies). The summary RR for each 100 mg/day increment in dietary vitamin C was 0.83 (95% CI: 0.75 to 0.93) (10 studies), and for each 20 μmol/L increment in circulating vitamin C was 0.81 (95% CI: 0.75 to 0.88) (5 studies). Few studies reported results for vitamin C supplements (RR for high-versus-low intake=0.83, 95% CI: 0.62 to 1.10, 3 studies).

CONCLUSIONS:

This meta-analysis suggests significant inverse relationships between dietary vitamin C intake, circulating vitamin C, and risk of stroke.

KEYWORDS:

antioxidants; diet; meta‐analysis; prevention; stroke

PMID:
24284213
PMCID:
PMC3886767
DOI:
10.1161/JAHA.113.000329
[Indexed for MEDLINE]
Free PMC Article

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