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Clin Implant Dent Relat Res. 2015 Aug;17(4):742-57. doi: 10.1111/cid.12179. Epub 2013 Nov 28.

Bone Formation in a Local Defect around Dental Implants Coated with Extracellular Matrix Components.

Author information

1
University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
2
Clinic of Oral & Maxillofacial Surgery, Technische Universität Dresden, Dresden, Germany.
3
Max Bergmann Center of Biomaterials, Technische Universität Dresden, Dresden, Germany.
4
Clinic of Cranio-Maxillofacial and Oral Surgery, University of Zurich, Zurich, Switzerland.

Abstract

PURPOSE:

The coating of implant surfaces with components of the extracellular matrix offers an approach to influence peri-implant bone healing. In this study, bone healing around coated implants is analyzed in a peri-implant defect model.

MATERIALS AND METHODS:

Eight months after extraction of the premolar teeth, six dogs received 48 implants (eight per animal) in the mandible. Implant surfaces were sandblasted and acid-etched, and some were additionally coated with collagen type II and chondroitin sulfate (collagen/CS). On each side of the mandible, implants either had no peri-implant defect (control side) or a vertical defect of 5 mm in depth and 0.5, 1.0, or 2.0 mm in width. Implants healed submerged for 8 weeks. Fluorochrome staining, histology, and histomorphometry were used to analyze implant osseointegration.

RESULTS:

Fluorochrome labels showed an increased mineralization around collagen/CS-coated surfaces at 4 weeks (p = .031). Histomorphometry generally showed lower vertical and horizontal bone apposition with increasing gap size for both surface types. In gapless sites and 0.5-mm gaps, collagen/CS coated implants showed increased bone volume in areas directly adjacent to the implant, in comparison with uncoated implants (p < .05).

CONCLUSION:

The width of the peri-implant gap influences peri-implant bone formation. Complete filling of all gaps by newly formed bone could not be observed around either surface. In proximity to the surface, implant surface coating by collagen/CS positively influenced bone formation.

KEYWORDS:

animal model; biocompatible; coated materials; dental implants; extracellular matrix; histology; osseointegration

PMID:
24283497
DOI:
10.1111/cid.12179
[Indexed for MEDLINE]

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