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AIDS Res Hum Retroviruses. 2014 Jun;30(6):592-7. doi: 10.1089/AID.2013.0196. Epub 2014 Feb 6.

HIV-1 genetic diversity in Russia: CRF63_02A1, a new HIV type 1 genetic variant spreading in Siberia.

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1
State Research Center of Virology and Biotechnology Vector , Novosibirsk, Russia .

Abstract

One of the factors determining a high degree of heterogeneity in the HIV population is recombination-based variation, which leads to the emergence of the virus variants with a mosaic genome. An example is CRF63_02A1, an HIV-1 variant currently spreading in the Siberian region of Russia. To prove that this HIV-1 variant is a new circulating recombinant form that had emerged as a result of repeated recombination between CRF02_AG and subtype A, we have isolated seven full-length HIV genomes and theoretically analyzed them, that is, reconstructed the phylogenetic relationships, determined recombination breakpoints and regions, and compared them with the regions known for CRF02_AG.

PMID:
24279614
PMCID:
PMC4046202
DOI:
10.1089/aid.2013.0196
[Indexed for MEDLINE]
Free PMC Article
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