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Aliment Pharmacol Ther. 2014 Jan;39(2):148-62. doi: 10.1111/apt.12562. Epub 2013 Nov 26.

Review article: management of chronic hepatitis C in patients with contraindications to anti-viral therapy.

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1
Fundación Estudio Hepatitis Virales, Madrid, Spain.

Abstract

BACKGROUND:

There are patients with chronic hepatitis C who are not eligible for the current interferon-based therapies or refuse to be treated due to secondary effects.

AIM:

To provide information on alternative treatments for the management of these patients.

METHODS:

A PubMed search was performed to identify relevant literature. Search terms included hepatitis C virus, anti-inflammatory treatment, antioxidant, natural products and alternative treatment, alone or in combination. Additional publications were identified using the references cited by primary and review articles.

RESULTS:

Several approaches, such as iron depletion (phlebotomy), treatment with ursodeoxycholic acid or glycyrrhizin, have anti-inflammatory and/or anti-fibrotic effects. Life interventions like weight loss, exercise and coffee consumption are associated with a biochemical improvement. Other alternatives (ribavirin monotherapy, amantadine, silibinin, vitamin supplementation, etc.) do not have any beneficial effect or need to be tested in larger clinical studies.

CONCLUSION:

There are therapeutic strategies and lifestyle interventions that can be used to improve liver damage in patients with chronic hepatitis C who cannot receive or refuse interferon-based treatments.

Comment in

PMID:
24279580
DOI:
10.1111/apt.12562
[Indexed for MEDLINE]
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