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Glob Adv Health Med. 2012 May;1(2):38-45. doi: 10.7453/gahmj.2012.1.2.009.

The Heart and Medicine: Exploring the Interconnectedness of Cardiometabolic-related Concerns Through a Systems Biology Approach.

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Joseph Lamb, MD, is director, Intramural Clinical Research, Metagenics, Gig Harbor, Washington; adjunct faculty, Institute for Functional Medicine, Gig Harbor; and medical director, KinDex Therapeutics, Seattle, Washington.


in English, Chinese, Spanish

Patients do not just wake up one morning with cardiac disease. Instead there is an extended preclinical phase during which lifestyle choices determine outcome. Recent advances in our understanding of oxidative stress, endocrine signaling, immune/inflammatory balance, and energy production illuminate opportunities for efficacious intervention. A thorough exploration of these pathophysiologies will allow physicians the opportunity to offer their patients a journey away from illness and disease to optimal wellness.


Cardiometabolic; atherosclerosis; cardiovascular disease; diabetes; dyslipidemia; functional medicine and emotional learning; heart; hypertension; metabolic syndrome; neuropsychology; psychophysiology; psychosocial development; systems biology

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