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Postepy Dermatol Alergol. 2013 Apr;30(2):73-6. doi: 10.5114/pdia.2013.34154. Epub 2013 Apr 12.

Serum concentrations of metalloproteinase 2, metalloproteinase 9 and granzyme B in contact eczema patients.

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1
Department of Public Health, Nicolaus Copernicus University, Ludwik Rydygier Medical College, Bydgoszcz, Poland. Head: Prof. Krzysztof Leksowski MD, PhD.

Abstract

INTRODUCTION:

Contact eczema is a common skin condition with complex etiology, variable clinical presentation and lengthy therapy duration. The mechanism of contact eczema is complex, since it is affected by multiple inflammatory mediators.

AIM:

To assess concentrations of metalloproteinase 2 (MMP-2), metalloproteinase 9 (MMP-9) and granzyme B (GzmB) in patients with contact eczema.

MATERIAL AND METHODS:

Seventy patients with contact eczema and 30 healthy persons as controls were included in the study. In all subjects, MMP-2, MMP-9 and GzmB were determined using ELISA immunoassay. In study group patients, concentrations were assayed in periods of disease exacerbation and remission. Obtained results were analyzed statistically.

RESULTS:

Mean MMP-2 and GzmB concentrations were found to be significantly higher in the study group than in the control group. Mean MMP-2, MMP-9 and GzmB levels were also statistically significantly higher during skin lesion relapse compared to contact eczema remission periods.

CONCLUSIONS:

The presented paper demonstrates that MMP-2, MMP-9 and GzmB are good markers of contact eczema exacerbations.

KEYWORDS:

contact eczema; granzyme; metalloproteinase

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