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Schizophr Res. 2014 Jan;152(1):124-9. doi: 10.1016/j.schres.2013.10.038. Epub 2013 Nov 22.

TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis.

Author information

1
Department of Psychiatry, McGill University, Canada.
2
Douglas Mental Health University Institute, Canada; Department of Human Genetics, McGill University, Canada.
3
Douglas Mental Health University Institute, Canada.
4
Douglas Mental Health University Institute, Canada; Department of Psychiatry, McGill University, Canada.
5
Douglas Mental Health University Institute, Canada; Department of Human Genetics, McGill University, Canada; Department of Psychiatry, McGill University, Canada; Integrated Program in Neuroscience, McGill University, Canada. Electronic address: ridha.joober@douglas.mcgill.ca.

Abstract

BACKGROUND:

Single nucleotide polymorphisms in TCF4 gene have been consistently associated with schizophrenia in genome wide association studies, including the C allele of rs9960767. However, its exact role in modulating the schizophrenia phenotype is not known.

AIMS:

To comprehensively investigate the relationship between rs9960767 risk allele (C) of TCF4 and cognitive performance in patients with first episode psychosis (FEP).

METHODS:

173 patients with FEP received a comprehensive neurocognitive evaluation and were genotyped for rs9960767. Carriers of the risk allele (CA/CC) were compared to non-carriers (AA) using Multivariate Analysis of Covariance MANCOVA. Ethnicity, negative symptoms and substance abuse were included as covariates.

RESULTS:

Carriers of the risk allele had a statistically significant lower performance in the cognitive domain of Reasoning/Problem-Solving compared to non-carriers (F1,172=4.4, p=.038). There were no significant genotype effects on the other cognitive domains or general cognition. This effect on the Reasoning/Problem-Solving domain remained significant even when controlling for IQ (F1,172=4.3, p=.039).

CONCLUSIONS:

rs9960767 (C) of TCF4 appears to be associated with neurocognitive deficits in the Reasoning/Problem-Solving cognitive domain, in patients with FEP. A confirmation of this finding in a larger sample and including other TCF4 polymorphisms will be needed to gain further validity of this result.

KEYWORDS:

First episode psychosis; Genetics; Psychotic disorders; Schizophrenia; TCF4; rs9960767

PMID:
24275585
DOI:
10.1016/j.schres.2013.10.038
[Indexed for MEDLINE]
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