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Clin Pediatr (Phila). 2014 May;53(5):444-8. doi: 10.1177/0009922813510204. Epub 2013 Nov 25.

Treatment of late-onset hearing loss in infants with congenital cytomegalovirus infection.

Author information

1
1Schneider Children's Medical Center of Israel, Petach Tikvah, Israel.

Abstract

OBJECTIVE:

To evaluate the effect of antiviral treatment on late-onset hearing loss in infants with congenital cytomegalovirus infection.

DESIGN:

The database of all infants who had normal hearing at birth, and treated for late-onset hearing loss was collected. The primary study endpoint was the need for a cochlear implant at the last follow-up visit.

RESULTS:

Twenty-one infants met the inclusion criteria. Brain stem-evoked response audiometry testing revealed hearing loss in 35 of 42 ears (83%). Mean age at diagnosis of hearing loss was 7.4 ± 3.7 months and onset of antiviral therapy 10.3 ± 7.8 months. None of the ears showed further deterioration as referred to pretreatment values. Hearing thresholds improved in 29 ears (69%). None of the patients needed a cochlear implant.

CONCLUSIONS:

In children with late-onset hearing loss due to cytomegalovirus infection, antiviral treatment appears to prevent further deterioration and produce improvement. Controlled studies are needed to verify this observation.

KEYWORDS:

brain stem–evoked response audiometry; congenital cytomegalovirus infection; ganciclovir/valganciclovir; sensorineural hearing loss

PMID:
24275215
DOI:
10.1177/0009922813510204
[Indexed for MEDLINE]

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