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Clin Liver Dis. 2014 Feb;18(1):249-67. doi: 10.1016/j.cld.2013.09.017. Epub 2013 Oct 24.

Host genetic variants in obesity-related nonalcoholic fatty liver disease.

Author information

1
Betty and Guy Beatty Center for Integrated Research, Center for Liver Disease, Inova Health System, Claude Moore Building, 3300 Gallows Road, Falls Church, VA 22042, USA.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a complex disease. The considerable variability in the natural history of the disease suggests an important role for genetic variants in the disease development and progression. There is evidence based on genome-wide association studies and/or candidate gene studies that genetic polymorphisms underlying insulin signaling, lipid metabolism, oxidative stress, fibrogenesis, and inflammation can predispose individuals to NAFLD. This review highlights some of the genetic variants in NAFLD.

KEYWORDS:

GWAS; Polymorphism; SNP; Steatosis

PMID:
24274878
DOI:
10.1016/j.cld.2013.09.017
[Indexed for MEDLINE]

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