Format

Send to

Choose Destination
See comment in PubMed Commons below
Annu Rev Physiol. 2014;76:333-63. doi: 10.1146/annurev-physiol-021113-170338. Epub 2013 Nov 21.

Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release.

Author information

1
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115; email: kaeser@hms.harvard.edu , wade_regehr@hms.harvard.edu.

Abstract

Most neuronal communication relies upon the synchronous release of neurotransmitters, which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a presynaptic bouton. However, neurotransmitters are also released asynchronously with a longer, variable delay following an action potential or spontaneously in the absence of action potentials. A compelling body of research has identified roles and mechanisms for synchronous release, but asynchronous release and spontaneous release are less well understood. In this review, we analyze how the mechanisms of the three release modes overlap and what molecular pathways underlie asynchronous and spontaneous release. We conclude that the modes of release have key fusion processes in common but may differ in the source of and necessity for Ca(2+) to trigger release and in the identity of the Ca(2+) sensor for release.

[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Support Center