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Pharm Res. 1986 Aug;3(4):244-8. doi: 10.1023/A:1016398915965.

In Vivo performance of ophthalmic preparations of betamethasone and phenylephrine hydrochloride in the rabbit eye: Effect of polyvinyl alcohol.

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1
Faculty of Pharmacy, Department of Pharmaceutics, Assiut University, Assiut, Egypt.

Abstract

The effect of different concentrations of polyvinyl alcohol 14000 and 72000 (PVA 14 and 72) on the activity of betamethasone and phenylephrine hydrochloride in the rabbit eye was investigated. The polymer of higher molecular weight exerts a more pronounced effect at relatively lower viscosities. Effects on the intraocular pressure are more responsive to changes in viscosity than those on pupillary response.

PMID:
24271590
DOI:
10.1023/A:1016398915965
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