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Pharm Res. 1986 Jun;3(3):170-2. doi: 10.1023/A:1016318125534.

Fungal metabolism of 4-methylprimaquine.

Author information

1
Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677.

Abstract

4-Methylprimaquine (4-MPQ), an 8-aminoquinoline antimalarial drug, was subjected to microbial metabolism studies in an effort to isolate, identify, and predict the probable mammalian metabolite(s). Preliminary screening with a number of strains of Aspergillus indicated that several species were capable of metabolizing 4-MPQ to one major metabolite based on thin-layer chromatographic analysis. Preparative scale conversion of 4-MPQ using whole-cell suspensions of Aspergillus ochraceus afforded one major metabolite (4-MPQ-I). Based on spectroscopic and chemical evidence, the structure of the metabolite is proposed as 6-methoxy-8-(3-carboxyl-l-methylpropylamino)-lepidine.

PMID:
24271524
DOI:
10.1023/A:1016318125534

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