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Purinergic Signal. 2014 Mar;10(1):157-87. doi: 10.1007/s11302-013-9399-7. Epub 2013 Nov 23.

Purinergic signalling in the reproductive system in health and disease.

Author information

1
Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK, g.burnstock@ucl.ac.uk.

Abstract

There are multiple roles for purinergic signalling in both male and female reproductive organs. ATP, released as a cotransmitter with noradrenaline from sympathetic nerves, contracts smooth muscle via P2X1 receptors in vas deferens, seminal vesicles, prostate and uterus, as well as in blood vessels. Male infertility occurs in P2X1 receptor knockout mice. Both short- and long-term trophic purinergic signalling occurs in reproductive organs. Purinergic signalling is involved in hormone secretion, penile erection, sperm motility and capacitation, and mucous production. Changes in purinoceptor expression occur in pathophysiological conditions, including pre-eclampsia, cancer and pain.

PMID:
24271059
PMCID:
PMC3944041
DOI:
10.1007/s11302-013-9399-7
[Indexed for MEDLINE]
Free PMC Article

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