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Neurosci Lett. 2014 Apr 17;565:53-8. doi: 10.1016/j.neulet.2013.11.015. Epub 2013 Nov 19.

Neuroprotection by astrocytes in brain ischemia: importance of microRNAs.

Author information

1
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: ybouyang@stanford.edu.
2
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA.
3
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
4
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: rona.giffard@stanford.edu.

Abstract

Astrocytes have been shown to protect neurons and increase their survival in many pathological settings. Manipulating astrocyte functions is thus an important strategy to enhance neuronal survival and improve outcome following cerebral ischemia. Increasing evidence supports the involvement of microRNAs (miRNA), some of them being astrocyte-enriched, in the regulation of cerebral ischemia. This mini review will focus on several recently reported astrocyte-enriched miRNAs (miR-181 and miR-29 families and miR-146a), their validated targets, regional expression and effects on outcome after cerebral ischemia.

KEYWORDS:

Astrocyte; Cerebral ischemia; miR-146a; miR-181; miR-29; microRNA

PMID:
24269978
PMCID:
PMC3972331
DOI:
10.1016/j.neulet.2013.11.015
[Indexed for MEDLINE]
Free PMC Article

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