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Exp Gerontol. 2014 Feb;50:1-8. doi: 10.1016/j.exger.2013.11.005. Epub 2013 Nov 22.

Coffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro.

Author information

1
Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China; Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
2
Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China. Electronic address: nkj0809@gmail.com.
3
Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
4
Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
5
Department of Pharmacology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
6
Division of Geriatric Pharmacotherapy, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
7
Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
8
Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.

Abstract

Sarcopenia is characterized by the age-related loss of muscle mass and strength, which results in higher mortality in aged people. One of the mechanisms of the sarcopenia is the loss in the function and number of muscle satellite cells. Chronic low-grade inflammation plays a central role in the pathogenesis of age-related sarcopenia. Accumulating evidence suggests that coffee, one of the most widely consumed beverages in the world, has potential pharmacological benefits such as anti-inflammatory and anti-oxidant effects. Since these effects may improve sarcopenia and the functions of satellite cells, we examined the effects of coffee on the skeletal muscles in an animal model using aged mice. In vivo, coffee treatment attenuated the decrease in the muscle weight and grip strength, increased the regenerating capacity of injured muscles, and decreased the serum pro-inflammatory mediator levels compared to controls. In vitro, using satellite cells isolated from aged mice, coffee treatment increased the cell proliferation rate, augmented the cell cycle, and increased the activation level of Akt intra-cellular signaling pathway compared to controls. These findings suggest that the coffee treatment had a beneficial effect on age-related sarcopenia.

KEYWORDS:

Aged mice; Akt signaling; Coffee; IL-6; Inflammation levels; Sarcopenia; Satellite cells; TA; TNF-α; eMyHC; embryonic myosin heavy chain; interleukin 6; tibialis anterior; tumor necrosis factor-alpha

PMID:
24269808
DOI:
10.1016/j.exger.2013.11.005
[Indexed for MEDLINE]

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