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FEBS Lett. 2014 Jan 3;588(1):99-104. doi: 10.1016/j.febslet.2013.11.014. Epub 2013 Nov 20.

MicroRNA-221 promotes colorectal cancer cell invasion and metastasis by targeting RECK.

Author information

1
Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
2
Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: luomengrenji@126.com.

Abstract

MicroRNAs (miRNAs) have recently emerged as regulators of metastasis. We provide insight into the behavior of miR-221 in colorectal cancer (CRC) metastasis by showing that miR-221 is significantly upregulated in metastatic CRC cell lines and tissues. miR-221 overexpression enhances, whereas miR-221 depletion reduces CRC cell migration and invasion in vitro and metastasis in vivo. We identify RECK as a direct target of miR-221, reveal its expression to be inversely correlated with miR-221 in CRC samples and show that its re-introduction reverses miR-221-induced CRC invasiveness. Collectively, miR-221 is an oncogenic miRNA which may regulate CRC migration and invasion through targeting RECK.

KEYWORDS:

Colorectal cancer; Metastasis; RECK; miR-221

PMID:
24269686
DOI:
10.1016/j.febslet.2013.11.014
[Indexed for MEDLINE]
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