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Arch Soc Esp Oftalmol. 2014 Aug;89(8):336-9. doi: 10.1016/j.oftal.2013.07.008. Epub 2013 Oct 5.

Hyperhomocysteinemia in chronic alcoholism: A case with retinal manifestations.

[Article in English, Spanish]

Author information

1
Departamento de Neuro-oftalmología, Hospital Clínico San Carlos, Madrid, España. Electronic address: laurapalmerof@gmail.com.
2
Departamento de Neuro-oftalmología, Hospital Clínico San Carlos, Madrid, España.

Abstract

CASE REPORT:

An alcoholic patient with loss of vision in his right eye and a peripapillar haemorrhage, who then presented with a venous thrombosis. Blood analysis revealed hyperhomocysteinemia with coagulation parameters within the normal range. In the follow-up he developed a bilateral optic neuropathy.

DISCUSSION:

An increase in homocysteine levels is common in alcoholics, and it has been considered a vascular risk factor. Folic acid and vitamins B6 and B12 deficiency may lead to hyperhomocysteinemia, as they participate in its metabolism.

CONCLUSIONS:

When presented with a retinal occlusive disease or ischemic optic neuropathy in young patients, coagulation disorders and elevated levels of homocysteine should be ruled out.

KEYWORDS:

Alcoholism; Alcoholismo; Hiperhomocisteinemia; Hyperhomocysteinemia; Neuropatía óptica; Oclusión venosa retiniana; Optic neuropathy; Retinal vein occlusion

PMID:
24269416
DOI:
10.1016/j.oftal.2013.07.008
[Indexed for MEDLINE]

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