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Chem Biol. 2014 Jan 16;21(1):16-37. doi: 10.1016/j.chembiol.2013.09.010. Epub 2013 Nov 21.

Glycotherapy: new advances inspire a reemergence of glycans in medicine.

Author information

1
Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
2
Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: crb@berkeley.edu.

Abstract

The beginning of the 20(th) century marked the dawn of modern medicine with glycan-based therapies at the forefront. However, glycans quickly became overshadowed as DNA- and protein-focused treatments became readily accessible. The recent development of new tools and techniques to study and produce structurally defined carbohydrates has spurred renewed interest in the therapeutic applications of glycans. This review focuses on advances within the past decade that are bringing glycan-based treatments back to the forefront of medicine and the technologies that are driving these efforts. These include the use of glycans themselves as therapeutic molecules as well as engineering protein and cell surface glycans to suit clinical applications. Glycan therapeutics offer a rich and promising frontier for developments in the academic, biopharmaceutical, and medical fields.

PMID:
24269151
PMCID:
PMC4111574
DOI:
10.1016/j.chembiol.2013.09.010
[Indexed for MEDLINE]
Free PMC Article

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