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Phytomedicine. 2014 Mar 15;21(4):534-40. doi: 10.1016/j.phymed.2013.10.020. Epub 2013 Nov 21.

Piperine production by endophytic fungus Colletotrichum gloeosporioides isolated from Piper nigrum.

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School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India.
Regional Forensic Laboratory, Kannur, Kerala.
School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India. Electronic address:


Many endophytic fungi have been reported with the biosynthetic potential to produce same or similar metabolites present in host plants. The adaptations that might have acquired by these fungi as a result of the long-term association with their host plants can be the possible basis of their biosynthetic potential. The bioactive compounds originated from endophytes are currently explored for their potential applications in pharmaceutical, agriculture and food industries. Piper nigrum, a plant of the Piperaceae is very remarkable because of the presence of the alkaloid piperine. Piperine has been reported to have broad bioactive properties ranging from antimicrobial, antidepressant, anti-inflammatory, antioxidative to anticancer activities. Interestingly, piperine also plays a vital role in increasing the bioavailability of many drugs which again is a promising property. The current study was carried out to identify piperine producing endophytic fungus from Piper nigrum L. By screening various endophytic fungi, the isolate which was identified as member of Colletotrichum gloeosporioides was found to have the ability to form piperine and was confirmed by HPLC and LCMS. Considering the broad bioactive potential of piperine, the piperine producing fungi identified in the study can expect to have much industrial potential.


Colletotrichum gloeosporioides; Endophytic fungi; LCMS; Piper nigrum; Piperine

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