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Reprod Biomed Online. 2014 Jan;28(1):64-9. doi: 10.1016/j.rbmo.2013.09.017. Epub 2013 Sep 27.

Probability of live birth in women with extremely low anti-Müllerian hormone concentrations.

Author information

1
Department of Perinatology, Medical University, Gdańsk, Poland; INVICTA Fertility and Reproductive Center, Gdańsk, Poland; Department of Obstetrics and Gynecological Nursing, Faculty of Health Sciences, Medical University of Gdansk, Poland; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Varmia and Masuria, Olsztyn, Poland.
2
INVICTA Fertility and Reproductive Center, Warszawa, Poland. Electronic address: michal.kunicki@invicta.pl.
3
INVICTA Fertility and Reproductive Center, Gdańsk, Poland.
4
INVICTA Fertility and Reproductive Center, Warszawa, Poland.
5
INVICTA Fertility and Reproductive Center, Warszawa, Poland; Department of Obstetrics and Gynaecology, Medical Center of Postgraduate Education, Warsaw, Poland.

Abstract

The aim of the present study was to investigate the clinical pregnancy and live birth rates in women with extremely low (≤ 0.4 ng/ml) anti-Müllerian hormone (AMH) concentrations. The study included 101 women (188 cycles) with extremely low AMH concentrations undergoing IVF cycles and compared the number of live births in women with low AMH. Moreover, the study compared the number of live births in women with or without endometriosis stage III/IV. Fourteen clinical pregnancies and 14 live births (including one pair of twins) were recorded; one woman miscarried. Significantly higher clinical pregnancy (P = 0.046) and live birth rates (P = 0.018) were found in women aged < 35 years compared with older women. AMH concentration did not differ significantly between women with or without endometriosis and there were six live births in women with endometriosis. This was not significantly different from the rate in healthy women. It is concluded that live births are possible in women with extremely low AMH concentrations. The presence of endometriosis stage III/IV did not affect live birth rates in women with extremely low AMH concentrations although an important limitation of the study is the small number of women included who were affected by that disease.

KEYWORDS:

AMH; DHEA; IVF; endometriosis; inhibin B; ovarian reserve

PMID:
24268729
DOI:
10.1016/j.rbmo.2013.09.017
[Indexed for MEDLINE]

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