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Fertil Steril. 2014 Jan;101(1):134-7. doi: 10.1016/j.fertnstert.2013.09.028. Epub 2013 Oct 23.

Impact of antimüllerian hormone assays on the outcomes of in vitro fertilization: a prospective controlled study.

Author information

1
Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt; The Egyptian IVF Center, Cairo, Egypt. Electronic address: gharmd@gmail.com.
2
Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt; The Egyptian IVF Center, Cairo, Egypt.
3
The Egyptian IVF Center, Cairo, Egypt.
4
The Egyptian IVF Center, Cairo, Egypt; Department of Obstetrics and Gynecology, Al-Azhar University, Cairo, Egypt.

Abstract

OBJECTIVE:

To assess the value of routine antimüllerian hormone (AMH) assays in patients considered high risk for cancellation.

DESIGN:

Prospective controlled study.

SETTING:

A private IVF center, Cairo, Egypt.

PATIENT(S):

In total 4,917 patients received counseling before starting IVF/intracytoplasmic sperm injection (ICSI). They were comprised of group A1 (n = 1,335), who were considered to be at risk for cancellation after ovarian stimulation, and group A2 (n = 3,582), who were considered low risk for cancellation. A control group, B (n = 4,639), included group B1 (n = 1,248) and group B2 (n = 3,391) based on the same criteria as groups A1 and A2.

INTERVENTION(S):

An AMH assessment was performed for group A1. All of the patients were stimulated using the long GnRH agonist protocol. Patients with low AMH levels received the flare-up protocol.

MAIN OUTCOME MEASURE(S):

The cancellation of IVF/ICSI cycles before or after stimulation, as well as the pregnancy rates (PR) in relation to AMH levels.

RESULT(S):

The group A1 patients (6.4%) did not start IVF due to low AMH, and some (6.6%) had their cycles canceled due to poor responses, compared with 2.6% in group A2 and 13.2% in group B1. The clinical PR was 42% in patients with normal AMH and 20% in patients with low AMH. The differences among these three groups were highly significant.

CONCLUSION(S):

The AMH assays reduced the cancellations, cost, and stress experienced by couples.

KEYWORDS:

AMH; IVF; cancellation rate; poor responder

[Indexed for MEDLINE]

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