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Schizophr Res. 2014 Jan;152(1):139-45. doi: 10.1016/j.schres.2013.09.021. Epub 2013 Nov 22.

A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence.

Author information

1
Department of Psychiatry, University of Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK; Centre for Mental Health, Addiction and Suicide Research, School of Social and Community Medicine, University of Bristol, UK. Electronic address: gmk24@medschl.cam.ac.uk.
2
Centre for Mental Health, Addiction and Suicide Research, School of Social and Community Medicine, University of Bristol, UK; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK.
3
Centre for Mental Health, Addiction and Suicide Research, School of Social and Community Medicine, University of Bristol, UK; University College London, London, UK.
4
Department of Psychiatry, University of Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.

Abstract

OBJECTIVE:

Schizophrenia is associated with atopy and increased inflammatory markers. We report a population-based longitudinal study of the associations between childhood atopic disorders, subsequent serum inflammatory markers, interleukin 6 (IL-6) and C-reactive protein (CRP), and the risk of psychotic experiences (PEs).

METHOD:

PEs were assessed at age 13 years (n=6785). Presence of clinician-diagnosed atopic disorders (asthma and eczema) was determined from parent-completed questionnaires at age 10 years (n=7814). Serum IL-6 and CRP were measured at age 9 years (n=5076). Logistic regression examined the association between (1) atopy and PEs, (2) inflammatory markers and PEs, and (3) mediating effects of inflammatory markers on the atopy-PEs association. Linear regression examined the association between atopy and inflammatory markers. Age, gender, social class, ethnicity and body mass index were included as potential confounders.

RESULTS:

At age 10 years, about 14% of the sample was reported to have asthma, 12% eczema, and 7% both asthma and eczema. Compared with children with no atopy, risk of PEs at age 13 years was increased for all of these groups; adjusted odds ratios (95% CI) were, respectively, 1.39 (1.10-1.77), 1.33 (1.04-1.69), and 1.44 (1.06-1.94). Atopy was associated with increased serum IL-6 and CRP; however, this did not mediate association between atopy and PEs. Inflammatory markers were not associated with later PEs.

CONCLUSION:

Childhood atopic disorders increase the risk of psychotic experiences in adolescence. Follow-up of these individuals will be useful to determine the effect of atopy and inflammation on different trajectories of early-life PEs.

KEYWORDS:

95% confidence interval; ALSPAC; Adolescence; Asthma; Atopic disorders; Birth cohort; C-reactive protein; CI; CRP; Childhood; Cytokine; Eczema; IL-6; Immunity; Inflammatory markers; OR; PEs; Prospective study; Psychotic experiences; Psychotic symptoms; Schizophrenia; interleukin 6; odds ratio, 95%; psychotic experiences

PMID:
24268471
PMCID:
PMC3906534
DOI:
10.1016/j.schres.2013.09.021
[Indexed for MEDLINE]
Free PMC Article

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