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Cell. 2013 Nov 21;155(5):990-6. doi: 10.1016/j.cell.2013.10.048.

Divergent transcription: a driving force for new gene origination?

Author information

1
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Computational and Systems Biology Graduate Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

The mammalian genome is extensively transcribed, a large fraction of which is divergent transcription from promoters and enhancers that is tightly coupled with active gene transcription. Here, we propose that divergent transcription may shape the evolution of the genome by new gene origination.

PMID:
24267885
PMCID:
PMC3899942
DOI:
10.1016/j.cell.2013.10.048
[Indexed for MEDLINE]
Free PMC Article

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