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Mol Cell. 2013 Nov 21;52(4):473-84. doi: 10.1016/j.molcel.2013.10.032.

Dealing with pervasive transcription.

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1
Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C., Denmark. Electronic address: thj@mb.au.dk.

Abstract

Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly found RNAs have functions and how many are byproducts of functional, or spurious, transcription events. Cells control the accumulation of many opportunistic transcripts by limiting their synthesis and by provoking their early transcription termination and decay. In this review, we use S. cerevisiae and mammalian cells as models to discuss the circumstances by which pervasive transcripts are produced and turned over. This ultimately relates to the likelihood, and potential mechanism, of molecular function.

PMID:
24267449
DOI:
10.1016/j.molcel.2013.10.032
[Indexed for MEDLINE]
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