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Chem Biol. 2013 Nov 21;20(11):1307-8. doi: 10.1016/j.chembiol.2013.11.001.

NAD as a genotype-specific drug target.

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1
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

Abstract

Using high-throughput chemical and genetic screening, Matheny and colleagues (in this issue of Chemistry & Biology) identified STF-118804, an inhibitor of nicotinamide phosphoribosyltransferase, as a cell type-specific inhibitor of mixed-lineage leukemia with MLL chromosomal rearrangements. The approach was powerful, as is the potential for NAD as a specific cancer target.

PMID:
24267273
PMCID:
PMC3907267
DOI:
10.1016/j.chembiol.2013.11.001
[Indexed for MEDLINE]
Free PMC Article
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