Progress of FtsZ inhibitors as novel antibiotics leads

Crit Rev Eukaryot Gene Expr. 2013;23(4):327-38. doi: 10.1615/critreveukaryotgeneexpr.2013007742.

Abstract

Bacterial cell division is an attractive target for new antibiotics. FtsZ is a major cytoskeletal protein widespread among archaea and bacteria. FtsZ has a filament-forming GTPase and a structural homologue of eukaryotic tubulin. FtsZ has been validated as a target for antibiotics. This review summarizes the chemical features, binding sites, mechanisms of action, and minimum inhibitory concentration of FtsZ inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects*
  • Bacteria / enzymology
  • Bacterial Proteins / metabolism*
  • Cytoskeletal Proteins / metabolism*
  • Enzyme Activation / drug effects
  • Enzyme Inhibitors / pharmacology*
  • GTP Phosphohydrolases / metabolism

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Cytoskeletal Proteins
  • Enzyme Inhibitors
  • FtsZ protein, Bacteria
  • GTP Phosphohydrolases