Abstract
Bacterial cell division is an attractive target for new antibiotics. FtsZ is a major cytoskeletal protein widespread among archaea and bacteria. FtsZ has a filament-forming GTPase and a structural homologue of eukaryotic tubulin. FtsZ has been validated as a target for antibiotics. This review summarizes the chemical features, binding sites, mechanisms of action, and minimum inhibitory concentration of FtsZ inhibitors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects*
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Bacteria / enzymology
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Bacterial Proteins / metabolism*
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Cytoskeletal Proteins / metabolism*
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Enzyme Activation / drug effects
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Enzyme Inhibitors / pharmacology*
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GTP Phosphohydrolases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Cytoskeletal Proteins
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Enzyme Inhibitors
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FtsZ protein, Bacteria
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GTP Phosphohydrolases