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Biomark Med. 2013 Dec;7(6):933-46. doi: 10.2217/bmm.13.85.

Prognostic significance of FRA expression in epithelial cancers using AQUA(®) technology.

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1
Department of Diagnostics Development, Morphotek, Inc., 210 Welsh Pool Road, Exton, PA 19341, USA.

Abstract

AIM:

Although agents that target FRA have advanced through clinical trials, comprehensive analyses of FRA expression in epithelial cancers compared with clinical variables and prognosis are limited.

MATERIALS & METHODS:

FRA expression was examined in non-small-cell lung cancer (NSCLC), ovarian cancer and endometrial cancer cohorts using AQUA(®) technology.

RESULTS:

For the NSCLC cohort, FRA expression was significantly higher in adenocarcinoma samples (p < 0.001) than other histologies, and in females (p = 0.003) versus males. High FRA expression was significantly associated with better survival in NSCLC cases (p = 0.01) while significantly and independently associated with worse prognosis in endometrial (p < 0.001) and ovarian cancers (p < 0.001).

CONCLUSION:

These studies confirm the prognostic value of FRA in multiple indications. The opposing prognostic effects observed may suggest differential biology.

PMID:
24266829
DOI:
10.2217/bmm.13.85
[Indexed for MEDLINE]
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