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PLoS Biol. 2013 Nov;11(11):e1001708. doi: 10.1371/journal.pbio.1001708. Epub 2013 Nov 12.

Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy.

Author information

1
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

Abstract

Several myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the lysosome and what significance this process has for muscle cells. We have established a Drosophila melanogaster model to study glycogen autophagy in skeletal muscles, using chloroquine (CQ) to simulate a vacuolar myopathy that is completely dependent on the core autophagy genes. We show that autophagy is required for the most efficient degradation of glycogen in response to starvation. Furthermore, we show that CQ-induced myopathy can be improved by reduction of either autophagy or glycogen synthesis, the latter possibly due to a direct role of Glycogen Synthase in regulating autophagy through its interaction with Atg8.

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PMID:
24265594
PMCID:
PMC3825659
DOI:
10.1371/journal.pbio.1001708
[Indexed for MEDLINE]
Free PMC Article

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