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Onco Targets Ther. 2013 Nov 15;6:1667-73. doi: 10.2147/OTT.S53565. eCollection 2013.

B7-H3 is a new cancer-specific endothelial marker in clear cell renal cell carcinoma.

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1
Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China ; Department of Oncology, Fudan University Shanghai Medical College, Shanghai, People's Republic of China.

Abstract

BACKGROUND:

The purpose of this study was to validate B7-H3 as a new cancer-specific endothelial marker in clear cell renal cell carcinoma.

METHODS:

B7-H3 expression patterns were compared between cancer and paired adjacent normal renal parenchyma by immunohistochemistry in paraffin-embedded specimens from 200 consecutive patients with clear cell renal cell carcinoma from January to December 2010. Four corpus luteum specimens were used as physiologic angiogenesis controls. B7-H3 messenger (m)RNA levels representing circulating endothelial cells were analyzed in 24 peripheral blood samples using real-time polymerase chain reaction. Collection and processing of tissue and peripheral blood samples was performed in compliance with the Declaration of Helsinki.

RESULTS:

Cancer cell-specific expression of B7-H3 was detected in 19% of clear cell renal cell carcinoma specimens, and tumor vasculature B7-H3 expression was confirmed in 98% (196) of cases. A diffuse pattern of vascular B7-H3 expression was associated with multiple adverse clinical and pathologic features (P<0.001). B7-H3 expression was not detected in paired adjacent normal renal parenchyma or vessels, or in luteal blood vessels. The B7-H3 mRNA level of circulating endothelial cells in peripheral blood was significantly higher in metastatic clear cell renal cell carcinoma (P<0.001).

CONCLUSION:

This pilot study indicates that B7-H3 is a cancer-specific endothelial marker of potential importance for the development of tumor-specific, vascular-targeted therapies, and is a prognostic marker in clear cell renal cell carcinoma.

KEYWORDS:

B7-H3; biomarkers; clear cell renal cell carcinoma; endothelial cell; kidney

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