Format

Send to

Choose Destination
See comment in PubMed Commons below
Br J Surg. 2013 Nov;100(12):1649-54. doi: 10.1002/bjs.9298.

Full-thickness laparoendoscopic colonic excision in an experimental model.

Author information

1
Department of Surgery and; Wolfson Unit for Endoscopy, St Mark's Hospital and Academic Institute.

Abstract

BACKGROUND:

Patients requiring surgery for complex colonic polyps traditionally undergo colectomy, with significant risks. Typically in excess of 10-30 cm of colon is removed at laparoscopic or open surgery lasting over 60 min. This study details the preclinical development of a rapid, minimally invasive, limited full-thickness colonic resection.

METHODS:

Both survival and non-survival procedures were performed in anaesthetized 70-kg pigs. A simulated colonic polyp was created by endoscopic ink injection with a clearance margin delineated by circumferential placement of mucosal argon plasma coagulation marks. Full-thickness eversion of the bowel was achieved using endoscopically placed anchors and the polyp was excised using a laparoscopic stapler. In survival procedures, pigs were killed under anaesthetic 8 days after surgery. All pigs underwent post-mortem examination.

RESULTS:

Five procedures were performed (5 pigs). The median (range) procedure duration was 26 (20-31) min, with a specimen diameter of 5.1 (4.5-6.3) cm. The postoperative recovery of survival animals (4 pigs) was uneventful. At post-mortem evaluation the resection sites were well healed with no evidence of stenosis, intra-abdominal infection or inadvertent organ damage. Histological assessment of anastomoses showed mucosal repair and restoration of submucosal continuity.

CONCLUSION:

Full-thickness localized colonic excision with this technique provides a large specimen with adequate healing in a porcine model.

PMID:
24264790
DOI:
10.1002/bjs.9298
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center