Format

Send to

Choose Destination
Mult Scler. 2014 Jun;20(7):854-61. doi: 10.1177/1352458513512708. Epub 2013 Nov 21.

Pupillary response to sparse multifocal stimuli in multiple sclerosis patients.

Author information

1
Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Australia eman_c5@yahoo.com.
2
Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Australia.
3
Department of Neurology, The Canberra Hospital, Australian National University Medical School, Australia.

Abstract

OBJECTIVES:

The objective of this paper is to investigate the pattern of abnormalities and establish the diagnostic power of multifocal objective pupil perimetry (mfPOP) in multiple sclerosis (MS).

METHODS:

A prospective study enrolling 35 normal (47.9 ± 16.8 years, 22 females) and 85 MS subjects (49.8 ± 11.3 years, 62 females; 72 relapsing-remitting (RR), and 13 primary or secondary progressives (PorS)). EDSS scores for the RR and PorS groups were 3.53 ± 1.04 (mean ± SD), and 5.9 ± 1.43, respectively. mfPOP responses were obtained from 44 regions/visual field. Each region was analysed according to response time-to-peak and standardised amplitude (AmpStd). Predictive power was measured by percentage area under the receiver operator curve (%AUC).

RESULTS:

mfPOP responses showed a significant reduction of 0.69 ± 0.04 dB (mean ± SE) in AmpStd and significantly delayed time-to-peak of 25.95 ± 0.89 ms (mean ± SE) in MS subjects compared to control subjects (p<0.001). %AUC was greater for time-to-peak than AmpStd both for RR and PorS patients. Diagnostic power followed the EDSS scores but not a history of optic neuritis.

CONCLUSIONS:

mfPOP is well tolerated and potentially has a role in the diagnosis and assessment of patients with MS.

KEYWORDS:

Multiple sclerosis; clinical neurophysiology; diagnostic test assessment; optic neuritis; perimetry; pupils

PMID:
24263384
DOI:
10.1177/1352458513512708
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center